Comedian Amy Schumer continues to prove that she’s willing to discuss literally anything—and her latest candid revelation is no exception. During a recent appearance on the“Not Skinny But Not Fat”podcast with Dear Media, the 44-year-old opened up about a botched colonoscopy that’s left her feeling decidedly unsexy, while reflecting on a much bigger health journey that fundamentally shifted how she sees herself.
The colonoscopy comment came as part of a larger conversation about Schumer’s current state of mind.“I feel happier than I’ve ever been before,”she shared, before casually dropping the detail about the procedure mishap that’s temporarily dampened her libido. While she didn’t elaborate on exactly what went wrong during the outpatient procedure—which typically involves a doctor examining the large intestine through a microscopic camera to screen for colorectal cancer—it’s just the latest health-related curveball in what’s been a transformative few years for the actress.
The bigger story here is how Schumer’s health challenges have become unexpectedly public. In 2024, she revealed she’d been diagnosed with exogenous Cushing syndrome, a condition brought on by high-dose steroid injections she’d been receiving. The syndrome left her with what’s clinically known as“moon face”—a round, red, and puffy appearance—which sparked a flood of cruel online comments about her changing looks. Rather than let it derail her, Schumer leaned into her signature transparency.“I wouldn’t have known if the internet hadn’t come for me so hard,”she reflected on the“Call Her Daddy”podcast in 2025, explaining how the public scrutiny actually led her to seek answers and get properly diagnosed.
Since then, her approach to wellness has shifted. She’s been using GLP-1 medications like Mounjaro to support her weight loss goals, and she’s also addressed perimenopause—something she initially didn’t realize was causing her symptoms. In a March 2025 social media video, Schumer detailed how hormone therapy with estrogen and progesterone transformed her quality of life.“My hair is fuller, my skin is better, I have more energy, I want to get down more, if you know what I mean. I’m talking about sex,”she said with characteristic humor. That’s what makes her so relatable: she refuses to sanitize her experience or pretend health conversations need to be clinical or shame-filled.
What’s striking about Schumer’s journey is how she’s reframed the narrative entirely. Instead of hiding her struggles or letting online cruelty define her, she’s weaponized her honesty into something powerful. Yes, she had a health scare. Yes, she’s dealing with perimenopause, hormonal shifts, and the occasional medical mishap. And yes, she’s choosing to talk about all of it—the sexual side effects, the good outcomes, the whole mess—because visibility matters. She’s currently separated from estranged husband Chris Fischer, with whom she shares son Gene, and she’s clearly in a place of reclaiming her body and her sense of agency.
The colonoscopy comment might seem like a throwaway joke, but it’s actually part of a larger pattern: Schumer normalizing conversations that most people keep private. That’s her superpower, and it’s exactly why people keep tuning in to hear what she’ll say next.
About the Author
Ava Hart
Ava Hart is a contributor to LocalBeat, covering local news and community stories.
